SCHEMBL7926767

SCHEMBL7926767

O=C(O)C1OC1c1ccc(OCc2ccccc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A1 P22736 1/20 0.55
NR4A2 P43354 1/20 0.55
NR4A3 Q92570 1/20 0.55
LMNA P02545 1/20 0.53
CYP1A2 P05177 1/20 0.53
PTGS1 P23219 1/20 0.53
SLC6A2 P23975 1/20 0.53
CYP2C19 P33261 1/20 0.53
PTGS2 P35354 1/20 0.53
SLC6A3 Q01959 1/20 0.53
HIF1A Q16665 1/20 0.53
HDAC6 Q9UBN7 1/20 0.53
MAOB P27338 1/20 0.53
PARP10 Q53GL7 1/20 0.53
GSK3B P49841 2/20 0.51
BACE1 P56817 2/20 0.51
SRD5A2 P31213 1/20 0.51
FFAR1 O14842 1/20 0.51
FFAR4 Q5NUL3 1/20 0.51
S1PR5 Q9H228 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9692676 0.86 NPC1 (0.53) NR4A1NR4A2NR4A3LMNACYP1A2
SCHEMBL5150643 0.85 KCNH2 (0.50) NR4A1NR4A2NR4A3LMNACYP1A2
SCHEMBL5150636 0.85 KCNH2 (0.50) NR4A1NR4A2NR4A3LMNACYP1A2
SCHEMBL4024959 0.83 MAOB (0.48) NR4A1NR4A2NR4A3LMNACYP1A2
SCHEMBL27902768 0.82 KDM4E (0.50) NR4A1NR4A2NR4A3LMNACYP1A2
SCHEMBL7344311 0.81 TSHR (0.54) MAOBPARP10PLA2G4BALDH1A1NPC1
SCHEMBL7344315 0.81 TSHR (0.54) MAOBPARP10PLA2G4BALDH1A1NPC1
SCHEMBL13911026 0.79 CYP2C19 (0.45) CYP1A2CYP2C19ALDH1A1NPC1
SCHEMBL2860575 0.79 CYP2C19 (0.45) CYP1A2CYP2C19ALDH1A1NPC1
SCHEMBL9798027 0.79 MAPT (0.43) CYP1A2CYP2C19BACE1FFAR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1124808-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF NEW ANTIDIABETIC AGENTS DR. REDDY'S RESEARCH FOUNDATION (IN) 2001-08-22 EP disclosed
WO-2000026200-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF NEW ANTIDIABETIC AGENTS DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-05-11 WO disclosed