Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9692676 | 0.86 | NPC1 (0.53) | MAOBTSHRNR4A1NR4A2NR4A3 | |
| SCHEMBL7926767 | 0.83 | NR4A1 (0.55) | MAOBNR4A1NR4A2NR4A3PARP10 | |
| SCHEMBL9488854 | 0.82 | TSHR (0.61) | MAOBTSHRMEN1KMT2ACYP1A2 | |
| SCHEMBL7772636 | 0.82 | TSHR (0.61) | MAOBTSHRMEN1KMT2ACYP1A2 | |
| SCHEMBL16303826 | 0.82 | TSHR (0.61) | MAOBTSHRMEN1KMT2ACYP1A2 | |
| SCHEMBL7770452 | 0.82 | TSHR (0.61) | MAOBTSHRMEN1KMT2ACYP1A2 | |
| SCHEMBL27902768 | 0.81 | KDM4E (0.50) | MAOBNR4A1NR4A2NR4A3KDM4E | |
| SCHEMBL14967144 | 0.81 | TSHR (0.45) | TSHRKDM4EMAPTPTGS2LMNA | |
| SCHEMBL7760857 | 0.81 | TSHR (0.45) | TSHRKDM4EMAPTPTGS2LMNA | |
| SCHEMBL29926003 | 0.78 | TSHR (0.45) | TSHRKDM4ELMNAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090216024-A1 | Processes for making pioglitazone and compounds of the processes | ZHU JIE | 2009-08-27 | — | — | US | disclosed |
| US-7541470-B2 | Processes for making pioglitazone and compounds of the processes | SYNTHON IP INC. (US) | 2009-06-02 | — | — | US | disclosed |
| US-20070167629-A1 | Processes for making pioglitazone and compounds of the processes | SYNTHON IP INC. | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090216024-A1 | Processes for making pioglitazone and compounds of the processes | PDK4, PDK2, DPP4 | MAOB 2235/4885TSHR 1096/4885NR4A1 1522/4885 |
| US-20070167629-A1 | Processes for making pioglitazone and compounds of the processes | PDK4, PDK2, DPP4 | MAOB 2235/4885TSHR 1096/4885NR4A1 1522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.