Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1998955 | 0.86 | ALDH1A1 (0.42) | ALDH1A1MAPTL3MBTL1LMNASCN9A | |
| SCHEMBL1997028 | 0.82 | GRM5 (0.39) | ALDH1A1MAPTL3MBTL1LMNASCN9A | |
| SCHEMBL9326920 | 0.71 | MEN1 (0.57) | ALDH1A1MAPTL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL2370957 | 0.70 | USP2 (0.42) | ALDH1A1MAPTL3MBTL1LMNASCN9A | |
| SCHEMBL9321390 | 0.69 | ALDH1A1 (0.58) | ALDH1A1MAPTL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL29693843 | 0.68 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNAHPGDNPC1 | |
| SCHEMBL191586 | 0.67 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL6631074 | 0.66 | CTNNB1 (0.58) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL2518071 | 0.66 | MAPT (0.65) | ALDH1A1MAPTL3MBTL1LMNAHPGD | |
| SCHEMBL471656 | 0.66 | HPGD (0.50) | ALDH1A1MAPTLMNASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010030954-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-03-18 | — | — | WO | disclosed |