Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL509845 | 0.84 | HPGD (0.58) | HPGDLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13666585 | 0.81 | HPGD (0.49) | HPGDLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2170651 | 0.81 | HPGD (0.57) | HPGDLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16562959 | 0.78 | KMT2A (0.52) | HPGDLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1536288 | 0.78 | HTT (0.55) | HPGDLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL26178673 | 0.78 | KMT2A (0.40) | HPGDKMT2ASMN1; SMN2TSHRHSP90AA1 | |
| SCHEMBL3739313 | 0.77 | HPGD (0.51) | HPGDLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL471629 | 0.77 | HPGD (0.61) | HPGDLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13144235 | 0.76 | HSP90AA1 (0.52) | HPGDLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29381824 | 0.76 | TSHR (0.75) | HPGDLMNAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2399577-A1 | Use of N-containing spirocompounds for the enhancement of cognitive function | Adolor Corporation (US) | 2011-12-28 | — | — | EP | disclosed |
| WO-2008033299-A2 | USE OF N-CONTAINING SPIROCOMPOUNDS FOR THE ENHANCEMENT OF COGNITIVE FUNCTION | ADOLOR CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |