Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 15/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 15/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 15/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 15/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 15/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 15/20 | 0.45 |
| ▸ | BRS3 | P32247 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7937436 | 0.89 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7937371 | 0.89 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7937519 | 0.86 | PSEN1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Hydrochloric Acid SCHEMBL7935741 | 0.80 | FNTA (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Hydrochloric Acid SCHEMBL7935975 | 0.75 | FNTA (0.52) | — | |
| Hydrochloric Acid SCHEMBL7935977 | 0.75 | FNTA (0.52) | — | |
| SCHEMBL7841577 | 0.74 | NOS2 (0.47) | BRS3KDM1A | |
| SCHEMBL7927444 | 0.73 | BRS3 (0.36) | BRS3 | |
| SCHEMBL8105207 | 0.73 | BRS3 (0.53) | BRS3HRH3 | |
| SCHEMBL7936786 | 0.71 | DAO (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001017992-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |