Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.45 |
| ▸ | BRS3 | P32247 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 2/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 2/20 | 0.35 |
| ▸ | FNTB | P49356 | 2/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7845559 | 0.90 | NOS2 (0.43) | NOS2SLC6A2SLC6A4SLC6A3BRS3 | |
| Hydrochloric Acid SCHEMBL7936809 | 0.81 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3BRS3MAPKAPK2 | |
| SCHEMBL6986524 | 0.80 | BRS3 (0.42) | SLC6A2SLC6A4BRS3TAAR1MAPKAPK2 | |
| SCHEMBL7936788 | 0.78 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3BRS3MAPKAPK2 | |
| Hydrochloric Acid SCHEMBL7936709 | 0.78 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3BRS3MAPKAPK2 | |
| SCHEMBL4682986 | 0.76 | SLC6A2 (0.62) | NOS2SLC6A2SLC6A4SLC6A3CCR5 | |
| SCHEMBL7939447 | 0.74 | BRS3 (0.54) | SLC6A2SLC6A4SLC6A3BRS3MAPKAPK2 | |
| SCHEMBL7927439 | 0.74 | PSEN1 (0.45) | BRS3KDM1A | |
| SCHEMBL7937519 | 0.74 | PSEN1 (0.38) | BRS3CCR5FNTAFNTBPGGT1B | |
| SCHEMBL6714998 | 0.73 | MAPKAPK2 (0.46) | MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |