Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 7/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.43 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7719347 | 1.00 | KLK5 (0.49) | KLK5KLK7CTSLBACE1CTSS | |
| Methane SCHEMBL7719349 | 0.89 | CTSL (0.47) | CTSLCTSSCTSKPSMB1PSMB8 | |
| SCHEMBL7718473 | 0.82 | KLK5 (0.54) | KLK5KLK7BACE1CTSSCTSK | |
| SCHEMBL5570005 | 0.77 | KLK5 (0.56) | KLK5KLK7BACE1CTSSCTSK | |
| SCHEMBL5570008 | 0.77 | KLK5 (0.56) | KLK5KLK7BACE1CTSSCTSK | |
| SCHEMBL7936792 | 0.76 | KLK5 (0.50) | KLK5KLK7BACE1CTSSCTSK | |
| SCHEMBL27983817 | 0.75 | KMT2A (0.51) | — | |
| SCHEMBL6555039 | 0.75 | HDAC4 (0.55) | KLK5CTSLCTSSCTSKKDM4E | |
| SCHEMBL15783809 | 0.74 | CHRM3 (0.49) | CTSSCTSKPSMB1PSMB8PSMB9 | |
| SCHEMBL14166143 | 0.74 | CHRM3 (0.61) | PSMB1PSMB8PSMB9PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001017992-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |