Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.50 |
| ▸ | KLK7 | P49862 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | CTSS | P25774 | 3/20 | 0.45 |
| ▸ | CTSK | P43235 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7718633 | 0.84 | ALDH1A1 (0.47) | KLK5HDAC1HDAC2KDM4EALDH1A1 | |
| SCHEMBL5570008 | 0.83 | KLK5 (0.56) | KLK5KLK7CTSSCTSKHDAC8 | |
| SCHEMBL5570005 | 0.83 | KLK5 (0.56) | KLK5KLK7CTSSCTSKHDAC8 | |
| SCHEMBL4485886 | 0.83 | PLAU (0.52) | HDAC1PTPN1 | |
| SCHEMBL7718473 | 0.81 | KLK5 (0.54) | KLK5KLK7CTSSCTSKBACE1 | |
| SCHEMBL6432668 | 0.78 | HDAC1 (0.46) | HDAC1PTPN1MEN1KMT2A | |
| SCHEMBL11036298 | 0.77 | HDAC4 (0.53) | KLK5KLK7HDAC1HDAC2KDM4E | |
| SCHEMBL5570659 | 0.77 | ALDH1A1 (0.49) | KLK5KLK7HDAC1KDM4EALDH1A1 | |
| SCHEMBL5570666 | 0.77 | ALDH1A1 (0.49) | KLK5KLK7HDAC1KDM4EALDH1A1 | |
| SCHEMBL7927451 | 0.76 | KLK5 (0.49) | KLK5KLK7KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001017992-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |