Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 5/20 | 0.36 |
| ▸ | CACNG8 | Q8WXS5 | 5/20 | 0.36 |
| ▸ | BCHE | P06276 | 6/20 | 0.35 |
| ▸ | ACHE | P22303 | 6/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312335 | 0.85 | CYP3A4 (0.38) | TSHRALDH1A1CYP3A4PIK3CAKMT2A | |
| SCHEMBL8978656 | 0.85 | KMT2A (0.38) | TSHRALDH1A1GRIA1CACNG8TRPV1 | |
| SCHEMBL3789699 | 0.80 | ALDH1A1 (0.47) | TSHRNR4A2ALDH1A1BCHEACHE | |
| SCHEMBL2095845 | 0.76 | GRIA1 (0.36) | GRIA1CACNG8TRPV1CYP1A2CYP2C19 | |
| SCHEMBL10873536 | 0.76 | GRIA1 (0.33) | GRIA1CACNG8TRPV1CYP1A2CYP2C19 | |
| SCHEMBL2091796 | 0.76 | GRIA1 (0.39) | ALDH1A1GRIA1CACNG8TRPV1CYP1A2 | |
| SCHEMBL2095848 | 0.76 | GRIA1 (0.33) | ALDH1A1GRIA1CACNG8TRPV1CYP1A2 | |
| SCHEMBL2091798 | 0.76 | TSHR (0.45) | TSHRALDH1A1GRIA1CACNG8TRPV1 | |
| SCHEMBL29937335 | 0.76 | GRIA1 (0.33) | GRIA1CACNG8TRPV1CYP1A2CYP2C19 | |
| SCHEMBL16957701 | 0.76 | GRIA1 (0.33) | GRIA1CACNG8TRPV1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235939-B1 | TRIFLUOROALKOXY-5-CHLOROANILINE | BAYER AKTIENGESELLSCHAFT (DE) | 2001-05-22 | — | — | US | claimed |
| EP-0546391-A2 | Process for the preparation of fluorine containing anilines. | BAYER AG (DE) | 1993-06-16 | — | — | EP | claimed |
| US-20240101576-A1 | HETEROCYCLIC INHIBITORS OF EGFR AND/OR HER2, FOR USE IN THE TREATMENT OF CANCER | ANTARES THERAPEUTICS, INC. | 2024-03-28 | — | — | US | disclosed |
| CN-116981667-A | Heterocyclic inhibitors of EGFR and/or HER2 for cancer treatment | 蝎子疗法股份有限公司 | 2023-10-31 | — | — | CN | disclosed |
| US-6235939-B1 | TRIFLUOROALKOXY-5-CHLOROANILINE | BAYER AKTIENGESELLSCHAFT (DE) | 2001-05-22 | — | — | US | disclosed |
| US-6077973-A | Process for the preparation of anilines which contain fluorine and new anilines which contain fluorine | BAYER AKTIENGESELLSCHAFT (DE) | 2000-06-20 | — | — | US | disclosed |
| EP-0546391-B1 | Process for the preparation of fluorine containing anilines. | BAYER AG (DE) | 1996-05-08 | — | — | EP | disclosed |
| EP-0546391-A2 | Process for the preparation of fluorine containing anilines. | BAYER AG (DE) | 1993-06-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240101576-A1 | HETEROCYCLIC INHIBITORS OF EGFR AND/OR HER2, FOR USE IN THE TREATMENT OF CANCER | ERBB2, EGFR, ERBB3 | TSHR 625/4885NR4A2 919/4885ALDH1A1 2700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.