Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.59 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ACACB | O00763 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL629952 | 0.88 | MAOB (0.74) | MAOBAPPLMNAHPGDNPC1 | |
| SCHEMBL15942083 | 0.86 | PTPN11 (0.56) | PTPN11LMNASMN1; SMN2CA12CA1 | |
| SCHEMBL1391085 | 0.85 | PTPN1 (0.51) | MAOBPTPN11PTPN1PTPN6APP | |
| Methyl 2,4-Dihydroxybenzoate SCHEMBL5199862 | 0.85 | MAOB (0.68) | MAOBAPPLMNAHPGDNPC1 | |
| SCHEMBL23405322 | 0.85 | FFAR4 (0.53) | MAOBPTPN11PTPN1PTPN6LMNA | |
| SCHEMBL29820043 | 0.81 | CA12 (0.65) | PTPN11LMNAHPGDNPC1SMN1; SMN2 | |
| SCHEMBL15603819 | 0.81 | CA12 (0.65) | PTPN11LMNAHPGDNPC1SMN1; SMN2 | |
| SCHEMBL15603818 | 0.80 | FFAR4 (0.48) | MAOBPTPN11PTPN1PTPN6LMNA | |
| SCHEMBL3712925 | 0.80 | ACACB (0.58) | MAOBPTPN11PTPN1PTPN6LMNA | |
| SCHEMBL710202 | 0.79 | MAOB (0.63) | MAOBAPPLMNAHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351743-A1 | BICYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010050445-A1 | BICYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2010-05-06 | — | — | WO | disclosed |