SCHEMBL7928477

SCHEMBL7928477

CCCOC(C)Oc1ccc2occc2c1

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CA2 P00918 7/20 0.43
CA12 O43570 5/20 0.43
CHRNB4 P30926 1/20 0.43
CHRNA3 P32297 1/20 0.43
CHRNA7 P36544 1/20 0.43
HTR1B P28222 5/20 0.40
MRGPRX4 Q96LA9 1/20 0.39
TAS1R3 Q7RTX0 1/20 0.38
TAS1R1 Q7RTX1 1/20 0.38
CTNNB1 P35222 2/20 0.36
WNT3A P56704 2/20 0.36
CYP2A6 P11509 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7928197 0.89 HTR1B (0.40) CA2CA12CHRNB4CHRNA3CHRNA7
SCHEMBL3791985 0.79 CA2 (0.47) CA2CA12CHRNB4CHRNA3CHRNA7
SCHEMBL3541660 0.79 CHRNB4 (0.56) CA2CA12CHRNB4CHRNA3CHRNA7
SCHEMBL3794109 0.78 CA2 (0.46) CA2CA12CHRNB4CHRNA3CHRNA7
SCHEMBL827016 0.75 CHRNB4 (0.56) CA2CA12CHRNB4CHRNA3CHRNA7
SCHEMBL7929535 0.75 TAS1R3 (0.35) CA2CA12TAS1R3TAS1R1
SCHEMBL7928373 0.74 CHRNB4 (0.51) CA2CA12CHRNB4CHRNA3CHRNA7
SCHEMBL7929541 0.73 TAS1R3 (0.36) TAS1R3TAS1R1
SCHEMBL7931710 0.72 CA9 (0.39) CA2CA12
SCHEMBL3791638 0.72 CA2 (0.51) CA2CA12CHRNB4CHRNA3CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140896-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 Takeda Chemical Industries, Ltd. (JP) 2001-10-10 EP disclosed
US-6235771-B1 AIDS THERPAY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-22 US disclosed
WO-2000037455-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-06-29 WO disclosed