Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | ESR1 | P03372 | 5/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.53 |
| ▸ | ESRRG | P62508 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7937782 | 0.91 | ESR1 (0.66) | ALDH1A1MEN1KMT2AGLAHPGD | |
| SCHEMBL7928818 | 0.90 | ESR1 (0.64) | ALDH1A1MEN1KMT2AGLAHPGD | |
| SCHEMBL7935209 | 0.85 | ESR1 (0.59) | MEN1KMT2AHPGDESR1ESR2 | |
| SCHEMBL7928961 | 0.84 | ESR1 (0.67) | ALDH1A1MEN1KMT2AGLAHPGD | |
| SCHEMBL7935136 | 0.83 | ESR1 (0.60) | ESR1ESR2ESRRG | |
| SCHEMBL7928850 | 0.82 | KDR (0.63) | ALDH1A1MEN1KMT2AGLAHPGD | |
| SCHEMBL7928963 | 0.81 | ESR1 (0.69) | ALDH1A1ESR1ESR2LMNA | |
| SCHEMBL8401838 | 0.78 | MEN1 (0.55) | ALDH1A1MEN1KMT2AGLAHPGD | |
| SCHEMBL8403699 | 0.78 | MEN1 (0.55) | ALDH1A1MEN1KMT2AESR1ESR2 | |
| SCHEMBL8594720 | 0.77 | MEN1 (0.53) | ALDH1A1MEN1KMT2AESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | claimed |
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |