Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 14/20 | 0.64 |
| ▸ | ESR2 | Q92731 | 14/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7937782 | 0.99 | ESR1 (0.66) | ESR1ESR2MEN1KMT2AHPGD | |
| SCHEMBL7935209 | 0.94 | ESR1 (0.59) | ESR1ESR2MEN1KMT2AHPGD | |
| SCHEMBL7928961 | 0.91 | ESR1 (0.67) | ESR1ESR2MEN1KMT2AHPGD | |
| SCHEMBL7928963 | 0.90 | ESR1 (0.69) | ESR1ESR2ALDH1A1 | |
| SCHEMBL7928773 | 0.90 | ALDH1A1 (0.58) | ESR1ESR2MEN1KMT2AHPGD | |
| SCHEMBL7928850 | 0.87 | KDR (0.63) | ESR1ESR2MEN1KMT2AHPGD | |
| SCHEMBL8594720 | 0.83 | MEN1 (0.53) | ESR1ESR2MEN1KMT2AALDH1A1 | |
| SCHEMBL7934984 | 0.82 | ESR1 (0.72) | ESR1ESR2 | |
| SCHEMBL8403699 | 0.82 | MEN1 (0.55) | ESR1ESR2MEN1KMT2AALDH1A1 | |
| SCHEMBL7937076 | 0.82 | ESR1 (0.66) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | claimed |
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |