Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 13/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 12/20 | 0.59 |
| ▸ | KDR | P35968 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7937782 | 0.95 | ESR1 (0.66) | ESR1ESR2KDRMEN1HPGD | |
| SCHEMBL7928850 | 0.94 | KDR (0.63) | ESR1ESR2KDRKDM4EMEN1 | |
| SCHEMBL7928818 | 0.94 | ESR1 (0.64) | ESR1ESR2KDRMEN1HPGD | |
| SCHEMBL7928961 | 0.89 | ESR1 (0.67) | ESR1ESR2KDRMEN1HPGD | |
| SCHEMBL7928963 | 0.86 | ESR1 (0.69) | ESR1ESR2 | |
| SCHEMBL7928773 | 0.85 | ALDH1A1 (0.58) | ESR1ESR2KDRKDM4EMEN1 | |
| SCHEMBL7928843 | 0.84 | ESR1 (0.66) | ESR1ESR2 | |
| SCHEMBL8402303 | 0.80 | KMT2A (0.50) | ESR1ESR2KDRKDM4EMEN1 | |
| SCHEMBL7928814 | 0.79 | ESR1 (0.64) | ESR1ESR2 | |
| SCHEMBL8403699 | 0.79 | MEN1 (0.55) | ESR1ESR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | claimed |
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |