Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | ANPEP | P15144 | 2/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | LAP3 | P28838 | 1/20 | 0.34 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945800 | 0.90 | ADAM17 (0.47) | ADAM17MMP2MMP9ANPEPLTA4H | |
| SCHEMBL7937743 | 0.86 | ADAM17 (0.65) | ADAM17MMP2MMP9ANPEPLTA4H | |
| SCHEMBL6942119 | 0.83 | ADAM17 (0.50) | ADAM17MMP2MMP9ANPEPLTA4H | |
| SCHEMBL6945376 | 0.83 | ADAM17 (0.49) | ADAM17MMP2MMP9ANPEPLTA4H | |
| SCHEMBL6945370 | 0.83 | ADAM17 (0.49) | ADAM17MMP2MMP9ANPEPLTA4H | |
| SCHEMBL6987312 | 0.82 | ADAM17 (0.46) | ADAM17MMP2MMP9ANPEPLTA4H | |
| SCHEMBL6946853 | 0.81 | ADAM17 (0.50) | ADAM17MMP2MMP9ANPEPLTA4H | |
| SCHEMBL6984710 | 0.81 | ADAM17 (0.45) | ADAM17CAPN1 | |
| SCHEMBL6984225 | 0.81 | ADAM17 (0.45) | ADAM17 | |
| SCHEMBL6988555 | 0.81 | ADAM17 (0.45) | ADAM17MMP2MMP9ANPEPLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |