Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 15/20 | 1.00 |
| ▸ | RARG | P13631 | 15/20 | 1.00 |
| ▸ | RARA | P10276 | 14/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.64 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.64 |
| ▸ | GOT1 | P17174 | 1/20 | 0.64 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29358433 | 1.00 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL29397204 | 1.00 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL7689383 | 0.87 | RARB (0.77) | RARBRARGRARAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9738342 | 0.86 | RARB (0.75) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL9944159 | 0.81 | RARB (0.74) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL13980228 | 0.81 | RARB (0.67) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL19639449 | 0.80 | RARB (0.67) | RARBRARGRARAMAPTSMN1; SMN2 | |
| SCHEMBL13980181 | 0.80 | RARB (0.66) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL14566563 | 0.80 | RARB (0.66) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL5827791 | 0.80 | RARB (0.66) | RARBRARGRARAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248791-B1 | Stimulating the differentiation of preadipocytic cells and therapies based thereon | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-06-19 | — | — | US | claimed |
| EP-0698392-B1 | Compositions containing a RAR alpha specific ligand and at least one fatty acid | CIRD GALDERMA (FR) | 2000-11-29 | — | — | EP | claimed |
| US-20240390334-A1 | COMPOSITIONS AND METHODS FOR MITIGATING ALCOHOL LIVER DISEASE | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2024-11-28 | — | — | US | disclosed |
| WO-2023044355-A1 | COMPOSITIONS AND METHODS FOR MITIGATING ALCOHOL LIVER DISEASE | CORNELL UNIVERSITY (US) | 2023-03-23 | — | — | WO | disclosed |
| US-20220347163-A1 | COMPOSITIONS AND METHODS FOR PROVIDING CARDIOPROTECTIVE EFFECTS | CORNELL UNIVERSITY (US) | 2022-11-03 | — | — | US | disclosed |
| US-20220304945-A1 | METHODS OF TREATING METABOLIC SYNDROME RELATED CONDITIONS USING RETINOIC ACID RECEPTOR AGONISTS | CORNELL UNIVERSITY (US) | 2022-09-29 | — | — | US | disclosed |
| US-20220296579-A1 | COMPOSITIONS AND METHODS FOR PROVIDING CARDIOPROTECTIVE EFFECTS | CORNELL UNIVERSITY (US) | 2022-09-22 | — | — | US | disclosed |
| CN-106211757-B | Methods of treating metabolic syndrome-related conditions using retinoic acid receptor agonists | 康奈尔大学 | 2022-06-07 | — | — | CN | disclosed |
| US-11207277-B2 | Methods of treating diseases associated with high-fat diet and vitamin a deficiency using retinoic acid receptor agonists | CORNELL UNIVERISITY (US) | 2021-12-28 | — | — | US | disclosed |
| US-11191755-B2 | Compositions and methods for providing cardioprotective effects | CORNELL UNIVERSITY (US) | 2021-12-07 | — | — | US | disclosed |
| US-11160769-B2 | Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists | CORNELL UNIVERSITY (US) | 2021-11-02 | — | — | US | disclosed |
| US-20160039747-A1 | Therapeutic Aryl-Amido-Aryl Compounds and Their Use | KING'S COLLEGE LONDON (GB) | 2016-02-11 | — | — | US | disclosed |
| US-20150352070-A1 | METHODS OF TREATING DISEASES ASSOCIATED WITH HIGH-FAT DIET AND VITAMIN A DEFICIENCY USING RETINOIC ACID RECEPTOR AGONISTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-12-10 | — | — | US | disclosed |
| EP-2945701-A1 | METHODS OF TREATING DISEASES ASSOCIATED WITH HIGH FAT DIET AND VITAMIN A DEFICIENCY USING RETINOIC ACID RECEPTOR AGONISTS | Cornell University (US) | 2015-11-25 | — | — | EP | disclosed |
| WO-2015138354-A1 | COMBINATION THERAPY FOR HEAD AND NECK CANCER | CORNELL UNIVERSITY (US) | 2015-09-17 | — | — | WO | disclosed |
| WO-2015109231-A1 | METHODS OF TREATING METABOLIC SYNDROME RELATED CONDITIONS USING RETINOIC ACID RECEPTOR AGONISTS | CORNELL UNIVERSITY (US) | 2015-07-23 | — | — | WO | disclosed |
| WO-2014113695-A1 | METHODS OF TREATING DISEASES ASSOCIATED WITH HIGH FAT DIET AND VITAMIN A DEFICIENCY USING RETINOIC ACID RECEPTOR AGONISTS | CORNELL UNIVERSITY (US) | 2014-07-24 | — | — | WO | disclosed |
| CN-1121857-C | RAR-gamma specific agonist ligands for increasing apoptosis rate | GENTRE INTERNAT DE RECH S DERM (FR) | 2003-09-24 | — | — | CN | disclosed |
| US-6248791-B1 | Stimulating the differentiation of preadipocytic cells and therapies based thereon | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-06-19 | — | — | US | disclosed |
| CN-1203528-A | RAR-gamma specific agonist ligands for increasing apoptosis rate | GENTRE INTERNATIONAL DE RECH D (FR) | 1998-12-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240390334-A1 | COMPOSITIONS AND METHODS FOR MITIGATING ALCOHOL LIVER DISEASE | NR1H3, NR1H2, RXRB | RARB 8/4885RARG 10/4885RARA 9/4885 |
| US-20220304945-A1 | METHODS OF TREATING METABOLIC SYNDROME RELATED CONDITIONS USING RETINOIC ACID RECEPTOR AGONISTS | RARA, RARG, RXRA | RARB 4/4885RARG 2/4885RARA 1/4885 |
| US-20220296579-A1 | COMPOSITIONS AND METHODS FOR PROVIDING CARDIOPROTECTIVE EFFECTS | RARB, RARG, RARA | RARB 1/4885RARG 2/4885RARA 3/4885 |
| US-11191755-B2 | Compositions and methods for providing cardioprotective effects | RARB, RARG, RARA | RARB 1/4885RARG 2/4885RARA 3/4885 |
| US-11160769-B2 | Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists | RARA, RARG, RXRA | RARB 5/4885RARG 2/4885RARA 1/4885 |
| US-20150352070-A1 | METHODS OF TREATING DISEASES ASSOCIATED WITH HIGH-FAT DIET AND VITAMIN A DEFICIENCY USING RETINOIC ACID RECEPTOR AGONISTS | RARA, RARB, RXRA | RARB 2/4885RARG 5/4885RARA 1/4885 |
| US-20220347163-A1 | COMPOSITIONS AND METHODS FOR PROVIDING CARDIOPROTECTIVE EFFECTS | RARB, RARG, RARA | RARB 1/4885RARG 2/4885RARA 3/4885 |
| US-20160039747-A1 | Therapeutic Aryl-Amido-Aryl Compounds and Their Use | RARA, RARB, RARG | RARB 2/4885RARG 3/4885RARA 1/4885 |
| US-11207277-B2 | Methods of treating diseases associated with high-fat diet and vitamin a deficiency using retinoic acid receptor agonists | RARA, RXRA, RARG | RARB 5/4885RARG 3/4885RARA 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.