Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6479763 | 0.78 | CHRM1 (0.41) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Bicarbonate SCHEMBL9845782 | 0.78 | CHRM1 (0.41) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL6380134 | 0.77 | TSHR (0.35) | TSHR | |
| SCHEMBL6366048 | 0.75 | SMPD1 (0.46) | LMNA | |
| SCHEMBL2252304 | 0.75 | TSHR (0.46) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL15008997 | 0.74 | — | — | |
| SCHEMBL7928839 | 0.73 | LMNA (0.33) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL2232093 | 0.71 | CHRM1 (0.48) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL26940421 | 0.71 | CHRM1 (0.48) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL13705648 | 0.71 | PRKCA (0.37) | CHRM1AKR1A1CHRM3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0903217-B1 | Cast-molding material for plastic lens and process for the production of plastic lens | HOYA CORP (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-6187888-B1 | CONTAINING, AS ESSENTIAL COMPONENTS, A COMBINATION OF DIETHYLENE GLYCOL BISALLYLCARBONATE OR A MIXTURE OF DIETHYLENE GLYCOL BISALLYLCARBONATE AND A MONOMER COPOLYMERIZABLE THEREWITH, AND A POLYETHER-MODIFIED SILICONE COMPOUND | HOYA CORPORATION | 2001-02-13 | — | — | US | disclosed |
| US-6056900-A | COMBINATION OF (A) DIETHYLENE GLYCOL BISALLYLCARBONATE OR A MIXTURE WITH A MONOMER COPOLYMERIZABLE THEREWITH, WITH (B) A POLYETHER-MODIFIED SILICONE COMPOUND; ALMOST FREE FROM CAUSING DEFECTIVE DYEING WHEN DYED | HOYA CORPORATION (JP) | 2000-05-02 | — | — | US | disclosed |
| EP-0903217-A2 | Cast-molding material for plastic lens and process for the production of plastic lens | Hoya Corporation (JP) | 1999-03-24 | — | — | EP | disclosed |