Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7921618 | 0.89 | USP30 (0.49) | GPR119USP30STSBCHEHTR6 | |
| SCHEMBL2189813 | 0.87 | CACNA1B (0.52) | GPR119USP30STSSFRP1TGFBR1 | |
| SCHEMBL7921625 | 0.80 | GPR119 (0.48) | GPR119USP30KAT6AKAT5MEN1 | |
| SCHEMBL2322336 | 0.79 | GPR119 (0.50) | GPR119USP30KAT6AKAT5MEN1 | |
| SCHEMBL2322344 | 0.79 | GPR119 (0.50) | GPR119USP30KAT6AKAT5MEN1 | |
| SCHEMBL2322341 | 0.79 | GPR119 (0.50) | GPR119USP30KAT6AKAT5MEN1 | |
| SCHEMBL17942540 | 0.76 | GPR119 (0.56) | GPR119STSMMP13TGFBR1 | |
| SCHEMBL3031564 | 0.76 | CACNA1B (0.52) | STSTGFBR1 | |
| SCHEMBL3035925 | 0.75 | CACNA1B (0.62) | GPR119STSMMP13TGFBR1 | |
| SCHEMBL21626630 | 0.74 | GPR119 (0.60) | GPR119STSEPHX2MMP13MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036589-A1 | SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK SHARP & DOHME CORP. (US) | 2010-04-01 | — | — | WO | disclosed |