Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7930215 | 0.88 | USP30 (0.51) | GPR119USP30MEN1KMT2AMAPT | |
| SCHEMBL2190031 | 0.87 | USP30 (0.45) | GPR119USP30KMT2AMAPTHPGD | |
| SCHEMBL2322336 | 0.81 | GPR119 (0.50) | GPR119USP30MEN1KMT2AMAPT | |
| SCHEMBL2322344 | 0.81 | GPR119 (0.50) | GPR119USP30MEN1KMT2AMAPT | |
| SCHEMBL2322341 | 0.81 | GPR119 (0.50) | GPR119USP30MEN1KMT2AMAPT | |
| SCHEMBL7928886 | 0.80 | GPR119 (0.47) | GPR119USP30MEN1KMT2AKAT6A | |
| SCHEMBL25571889 | 0.77 | GPR119 (0.57) | GPR119MEN1KMT2AMAPTNPC1 | |
| SCHEMBL3038735 | 0.77 | RORC (0.42) | GPR119MAPTNPSR1L3MBTL1 | |
| SCHEMBL21626597 | 0.75 | GPR119 (0.62) | GPR119MEN1KMT2AMAPT | |
| SCHEMBL3043410 | 0.75 | GPR119 (0.46) | GPR119MAPTNPC1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036589-A1 | SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK SHARP & DOHME CORP. (US) | 2010-04-01 | — | — | WO | disclosed |