Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199056 | 0.84 | TBXAS1 (0.51) | TBXAS1SMN1; SMN2ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL7931118 | 0.77 | TBXAS1 (0.48) | TBXAS1SMN1; SMN2NPC1ALDH1A1CYP1A2 | |
| SCHEMBL10193816 | 0.76 | TBXAS1 (0.57) | TBXAS1ALDH1A1NPSR1CYP3A4CYP2D6 | |
| SCHEMBL7276135 | 0.74 | KMT2A (0.52) | TBXAS1SMN1; SMN2ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL9720311 | 0.74 | TBXAS1 (0.46) | TBXAS1SMN1; SMN2NPC1ALDH1A1TP53 | |
| SCHEMBL4958496 | 0.72 | CHRNB2 (0.59) | TBXAS1NPC1RAB9ACYP2D6CYP2C9 | |
| SCHEMBL4958488 | 0.72 | CHRNB2 (0.59) | TBXAS1NPC1RAB9ACYP2D6CYP2C9 | |
| SCHEMBL3128200 | 0.72 | TBXAS1 (0.61) | TBXAS1SMN1; SMN2ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL9720318 | 0.71 | TBXAS1 (0.68) | TBXAS1CYP1A2CYP2C9CYP2C19LMNA | |
| SCHEMBL7518865 | 0.70 | TBXAS1 (0.45) | TBXAS1NPC1ALDH1A1RAB9AF7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056458-A4 | METHOD FOR THE TREATMENT OF PAIN, INCLUDING CHRONIC AND FEMALE SPECIFIC PAIN | UNIV WAKE FOREST (US) | 2001-06-20 | — | — | EP | disclosed |
| EP-1056458-A1 | METHOD FOR THE TREATMENT OF PAIN, INCLUDING CHRONIC AND FEMALE SPECIFIC PAIN | Wake Forest University (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999043322-A1 | METHOD FOR THE TREATMENT OF PAIN, INCLUDING CHRONIC AND FEMALE SPECIFIC PAIN | WAKE FOREST UNIVERSITY (US) | 1999-09-02 | — | — | WO | disclosed |