Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ4 | P56696 | 3/20 | 0.43 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234330 | 0.83 | HDAC1 (0.54) | HDAC3HDAC1HDAC2HDAC8HDAC10 | |
| SCHEMBL7940675 | 0.82 | KCNQ4 (0.47) | KCNQ4KCNQ5HDAC3HDAC1HDAC2 | |
| SCHEMBL3232171 | 0.82 | HDAC1 (0.55) | HDAC3HDAC1NCOR2 | |
| SCHEMBL6558791 | 0.81 | MAPT (0.52) | KCNQ4KCNQ5POLBMAPTMAPK1 | |
| SCHEMBL7935269 | 0.78 | HDAC1 (0.51) | KCNQ4KCNQ5HDAC3HDAC1HDAC2 | |
| SCHEMBL7939194 | 0.77 | METAP1 (0.51) | HDAC3HDAC1TP53MAPK1L3MBTL1 | |
| SCHEMBL7929314 | 0.77 | HDAC3 (0.52) | HDAC3HDAC1HDAC2HDAC8HDAC10 | |
| SCHEMBL7924031 | 0.77 | HDAC3 (0.64) | HDAC3HDAC1HDAC6NCOR2 | |
| SCHEMBL7935556 | 0.76 | — | — | |
| SCHEMBL7935007 | 0.74 | HDAC3 (0.69) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |