Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235360 | 0.84 | HDAC3 (0.72) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL7933392 | 0.79 | MAPT (0.53) | HDAC3HDAC1MAPTMAPK1TDP1 | |
| SCHEMBL6561044 | 0.78 | MAPT (0.58) | HDAC3HDAC1MAPTMAPK1TDP1 | |
| SCHEMBL7929328 | 0.77 | KCNQ4 (0.43) | HDAC3HDAC1MAPTMAPK1HDAC2 | |
| SCHEMBL13298958 | 0.76 | GAA (0.56) | HDAC3HDAC1MAPTHDAC4HDAC2 | |
| SCHEMBL8152611 | 0.75 | PTGS2 (0.42) | HDAC3HDAC1MAPK1HDAC4HDAC2 | |
| SCHEMBL7932753 | 0.75 | HDAC3 (0.47) | HDAC3HDAC1MAPTMAPK1HDAC4 | |
| SCHEMBL1061122 | 0.72 | HDAC3 (0.82) | HDAC3HDAC1MAPTHDAC4HDAC2 | |
| SCHEMBL27909121 | 0.71 | HDAC3 (0.79) | HDAC3HDAC1MAPTHDAC4HDAC2 | |
| SCHEMBL8161847 | 0.69 | GAA (0.61) | HDAC3HDAC1MAPTHDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |