Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5853030 | 0.80 | LMNA (0.38) | LMNANPSR1SMN1; SMN2P2RX7GAA | |
| Hydrochloric Acid SCHEMBL5852892 | 0.80 | LMNA (0.38) | LMNANPSR1SMN1; SMN2P2RX7GAA | |
| Hydrochloric Acid SCHEMBL5853362 | 0.78 | LMNA (0.38) | LMNANPSR1SMN1; SMN2P2RX7GAA | |
| Hydrochloric Acid SCHEMBL5853463 | 0.76 | HDAC8 (0.34) | LMNANPSR1SMN1; SMN2P2RX7GAA | |
| Hydrochloric Acid SCHEMBL5853700 | 0.76 | HDAC8 (0.34) | LMNANPSR1SMN1; SMN2P2RX7GAA | |
| Hydrochloric Acid SCHEMBL5853831 | 0.75 | LMNA (0.34) | LMNANPSR1SMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL2116546 | 0.73 | NPSR1 (0.38) | LMNANPSR1SMN1; SMN2P2RX7GAA | |
| Hydrochloric Acid SCHEMBL2116834 | 0.73 | NPSR1 (0.38) | LMNANPSR1SMN1; SMN2P2RX7GAA | |
| Hydrochloric Acid SCHEMBL5853512 | 0.71 | HDAC8 (0.34) | LMNANPSR1SMN1; SMN2P2RX7GAA | |
| Hydrochloric Acid SCHEMBL5854813 | 0.71 | HDAC8 (0.34) | LMNANPSR1SMN1; SMN2P2RX7GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225426-B1 | LIQUID PHASE POLYMERIZATION OF ETHYLENE, ALPHA-OLEFIN AND DIENE IN PRESENCE OF CATALYST COMPRISING MIXTURE OF METALLOCENE PROCATALYST AND ALUMINOXANE OR ALUMINOXANE AND TRIALKYLALUMINUM COMPOUND TOPRODUCE ELASTOMER | UNIROYAL CHEMICAL COMPANY, INC. | 2001-05-01 | — | — | US | disclosed |
| US-6147025-A | SUBSTITUTING PART OR ALL OF THE ALUMINOXANE COCATALYST WITH A CATION-GENERATING COCATALYST | UNIROYAL CHEMICAL COMPANY, INC, (US) | 2000-11-14 | — | — | US | disclosed |
| US-6136744-A | CATION-GENERATING COCATALYST COMPRISES A METAL COMPONENT, E.G., AN ALUMINUM COMPOUND, (2) A NEUTRAL METAL CONTAINING COMPONENT, E.G., A BORANE COMPOUND, AND (3) AN ANIONIC METAL COMPONENT, E.G., A METAL TETRAKIS(TETRAFLUOROPHENYL)BORATE. | UNIROYAL CHEMICAL COMPANY, INC. (US) | 2000-10-24 | — | — | US | disclosed |