Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 13/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8840105 | 0.78 | SLC6A4 (0.44) | SLC6A4SLC6A2SLC6A3MAOAMEN1 | |
| SCHEMBL7082101 | 0.77 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3MAOAMEN1 | |
| SCHEMBL5633593 | 0.73 | IDO1 (0.46) | MEN1KMT2ACYP1A2MAPT | |
| SCHEMBL385188 | 0.73 | SLC6A4 (0.52) | SLC6A4SLC6A2SLC6A3MAOAMEN1 | |
| SCHEMBL13026656 | 0.72 | SLC6A4 (0.56) | SLC6A4SLC6A2SLC6A3MAOAMEN1 | |
| SCHEMBL10996987 | 0.71 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3MAOAMEN1 | |
| SCHEMBL83839 | 0.71 | ALDH1A1 (0.58) | SLC6A4SLC6A2SLC6A3MAOANOS3 | |
| SCHEMBL1977989 | 0.70 | CYP2A6 (0.44) | NOS1 | |
| SCHEMBL257109 | 0.70 | MEN1 (0.55) | SLC6A4SLC6A2SLC6A3MAOAMEN1 | |
| Bromide SCHEMBL5449600 | 0.70 | MEN1 (0.47) | SLC6A4SLC6A2SLC6A3MAOAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300346-B1 | THERAPY OF PRECANCEROUS LESIONS COMPRISING ADMINISTERING INDENYL HYDROXAMIC ACID DERIVATIVE COMPOUND | CELL PATHWAYS, INC. | 2001-10-09 | — | — | US | disclosed |
| US-6071934-A | PREVENTING TUMORS OR SLOWING THEIR GROWTH | CELL PATHWAYS, INC. (US) | 2000-06-06 | — | — | US | disclosed |
| US-5093356-A | Antiallergens, antiasthma, antiinflammatory, cytoprotective | MERCK FROSST CANADA, INC. (CA) | 1992-03-03 | — | — | US | disclosed |
| US-4499287-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1985-02-12 | — | — | US | disclosed |
| US-4456761-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1984-06-26 | — | — | US | disclosed |
| US-4356182-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-10-26 | — | — | US | disclosed |
| US-4291040-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1981-09-22 | — | — | US | disclosed |