SCHEMBL257109

SCHEMBL257109

CCc1ccc(SC)cc1

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
KDM4E B2RXH2 1/20 0.55
ATM Q13315 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
SLC6A4 P31645 14/20 0.54
MAOA P21397 1/20 0.52
SLC6A2 P23975 1/20 0.52
SLC6A3 Q01959 1/20 0.52
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
TP53 P04637 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9934395 0.93 SLC6A4 (0.50) MEN1KMT2AKDM4EATMSMN1; SMN2
SCHEMBL16316305 0.87 SMN1; SMN2 (0.46) MEN1KMT2AKDM4EATMSMN1; SMN2
SCHEMBL18159470 0.80 TP53 (0.48) MEN1KMT2AKDM4EATMSMN1; SMN2
SCHEMBL576175 0.80 TP53 (0.48) MEN1KMT2AKDM4EATMSMN1; SMN2
SCHEMBL775853 0.80 TP53 (0.48) MEN1KMT2AKDM4EATMSMN1; SMN2
SCHEMBL13026656 0.80 SLC6A4 (0.56) MEN1KMT2ASLC6A4MAOASLC6A2
SCHEMBL6796574 0.79 SLC6A4 (0.53) MEN1KMT2ASLC6A4MAOASLC6A2
SCHEMBL16710872 0.79 TP53 (0.42) MEN1KMT2AKDM4EATMSMN1; SMN2
SCHEMBL83839 0.78 ALDH1A1 (0.58) MEN1KMT2ASLC6A4MAOASLC6A2
SCHEMBL36295 0.78 TP53 (0.67) ATMSMN1; SMN2CYP1A2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 275 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116535339-B Space conjugated organic molecule based on naphthalene skeleton and preparation and application thereof 桂林理工大学 2025-02-18 CN disclosed
US-20240066038-A1 WNT MODULATORS TO TREAT CENTRAL NERVOUS SYSTEM INJURIES MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2024-02-29 US disclosed
WO-2023183520-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER A2A PHARMACEUTICALS, INC. (US) 2023-09-28 WO disclosed
CN-116535339-A Space conjugated organic molecule based on naphthalene skeleton and preparation and application thereof 桂林理工大学 2023-08-04 CN disclosed
WO-2023141432-A2 APOL1 INHIBITORS AND METHODS OF USE MAZE THERAPEUTICS, INC. (US) 2023-07-27 WO disclosed
US-20230183286-A1 NOVEL 3' END CAPS, 5' END CAPS AND COMBINATIONS THEREOF FOR THERAPEUTIC RNA NOVARTIS AG (CH) 2023-06-15 US disclosed
US-20230183286-A1 NOVEL 3' END CAPS, 5' END CAPS AND COMBINATIONS THEREOF FOR THERAPEUTIC RNA NOVARTIS AG (CH) 2023-06-15 US disclosed
US-20230015617-A1 PHTHALAZINONE DERIVATIVES KUDOS PHARMACEUTICALS LIMITED (GB) 2023-01-19 US disclosed
EP-3914458-B1 SECURITY ELEMENT BASF SE (DE) 2022-12-21 EP disclosed
WO-2022104113-A1 SUBSTITUTED MONO- AND POLY-PHENYL-CORE MONOMERS AND POLYMERS THEREOF FOR VOLUME BRAGG GRATINGS FACEBOOK TECHNOLOGIES, LLC (US) 2022-05-19 WO disclosed
US-7169890-B2 Process for the production of ramoplanin-like amide derivatives VICURON PHARMACEUTICALS INC. (US) 2007-01-30 US disclosed
WO-2006117548-A1 HYDROXAMIC ACID DERVICATIVES AS INHIBITORS OF HDAC ENZYMATIC ACTIVITY CHROMA THERAPEUTICS LTD (GB) 2006-11-09 WO disclosed
US-20060241132-A1 Spiro derivatives and adhesion molecule inhibitors comprising the same as active ingredient TORAY INDUSTRIES, INC. A CORPORATION OF JAPAN (JP) 2006-10-26 US disclosed
EP-1489081-A1 SPIRO DERIVATIVES AND ADHESION MOLECULE INHIBITORS COMPRISING THE SAME AS THE ACTIVE INGREDIENT TORAY INDUSTRIES, INC. (JP) 2004-12-22 EP disclosed
EP-1329160-A2 4-ACYLAMINOPYRAZOLE DERIVATIVES Sankyo Company, Limited (JP) 2003-07-23 EP disclosed
EP-1304325-A1 5-(M-CYANOBENZYLAMINO)PYRAZOLE DERIVATIVES Sankyo Company, Limited (JP) 2003-04-23 EP disclosed
US-4389413-A 9,11-Methano-13-aza-11a-carbathrombanoic acid analogues ONO PHARMACEUTICAL CO. LTD. (JP) 1983-06-21 US disclosed
EP-0044711-A1 9,11-Methano-13-aza-11a-carbathrombanoic acid analogues and pharmaceutical use thereof ONO PHARMACEUTICAL CO., LTD. (JP) 1982-01-27 EP disclosed
US-4259330-A Nematocidal phosphoramidates ROHM AND HAAS COMPANY (US) 1981-03-31 US disclosed
US-4134993-A BENZOPHENONE DERIVATIVES ELI LILLY AND COMPANY (US) 1979-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230183286-A1 NOVEL 3' END CAPS, 5' END CAPS AND COMBINATIONS THEREOF FOR THERAPEUTIC RNA RNGTT, NSUN2, NSUN3 MEN1 3349/4885KMT2A 1755/4885KDM4E 1565/4885
US-20060241132-A1 Spiro derivatives and adhesion molecule inhibitors comprising the same as active ingredient VCAM1, SELL, ICAM1 MEN1 4337/4885KMT2A 2992/4885KDM4E 3531/4885
US-20230015617-A1 PHTHALAZINONE DERIVATIVES NR0B1, NR0B2, NR2E1 MEN1 1419/4885KMT2A 2142/4885KDM4E 3328/4885
US-20240066038-A1 WNT MODULATORS TO TREAT CENTRAL NERVOUS SYSTEM INJURIES WNT3A, WNT1, WNT3 MEN1 3656/4885KMT2A 3514/4885KDM4E 4322/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.