Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7931544 | 0.86 | CNR2 (0.50) | CNR2GRM5ALDH1A1NPC1RAB9A | |
| SCHEMBL7930354 | 0.84 | SMN1; SMN2 (0.47) | CNR2GRM5ALDH1A1SIRT2KCNMA1 | |
| SCHEMBL7934025 | 0.84 | NPC1 (0.49) | GRM5ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7930350 | 0.82 | POLB (0.51) | SIRT2KCNMA1NPC1RAB9AMEN1 | |
| SCHEMBL7922479 | 0.81 | JAK2 (0.46) | GRM5MEN1KMT2AL3MBTL1JAK2 | |
| SCHEMBL7929316 | 0.81 | GCK (0.62) | GRM5ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL7929299 | 0.80 | KCNQ3 (0.43) | GRM5MAPK14JAK2 | |
| SCHEMBL3377871 | 0.79 | MAPK14 (0.46) | GRM5ALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL7921912 | 0.79 | — | — | |
| SCHEMBL7930895 | 0.77 | PSMD14 (0.43) | CNR2GRM5ALDH1A1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |