Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | STAMBP | O95630 | 1/20 | 0.43 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | SCD | O00767 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7934017 | 0.81 | NPC1 (0.53) | KDM4EPOLBRAB9AGAAMAPK1 | |
| SCHEMBL7929316 | 0.77 | GCK (0.62) | KDM4EPOLBRAB9ASCDALDH1A1 | |
| SCHEMBL7930732 | 0.77 | CNR2 (0.53) | KDM4ERAB9ACNR2ALDH1A1GRM5 | |
| SCHEMBL7930354 | 0.77 | SMN1; SMN2 (0.47) | KDM4EPOLBCNR2ALDH1A1GRM5 | |
| SCHEMBL7931544 | 0.77 | CNR2 (0.50) | KDM4EPOLBRAB9ACNR2GAA | |
| SCHEMBL3377892 | 0.76 | GRM5 (0.57) | KDM4ERAB9AGAAALDH1A1GRM5 | |
| SCHEMBL3377871 | 0.76 | MAPK14 (0.46) | KDM4ERAB9AALDH1A1GRM5 | |
| SCHEMBL7930350 | 0.75 | POLB (0.51) | PSMD14POLBRAB9AGAA | |
| SCHEMBL7922479 | 0.74 | JAK2 (0.46) | GAAGRM5 | |
| SCHEMBL7929299 | 0.73 | KCNQ3 (0.43) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |