Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7930350 | 0.84 | POLB (0.51) | NPC1MEN1GAAMAPTKMT2A | |
| SCHEMBL7930895 | 0.81 | PSMD14 (0.43) | MAPK1ALDH1A1KDM4EGAAPOLB | |
| SCHEMBL7922479 | 0.80 | JAK2 (0.46) | MEN1GAAKMT2ALMNACYP3A4 | |
| SCHEMBL7930354 | 0.79 | SMN1; SMN2 (0.47) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL7931544 | 0.77 | CNR2 (0.50) | NPC1MAPK1ALDH1A1KDM4EHPGD | |
| SCHEMBL3377871 | 0.77 | MAPK14 (0.46) | NPC1ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL7930732 | 0.76 | CNR2 (0.53) | NPC1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3377892 | 0.75 | GRM5 (0.57) | NPC1ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL11626565 | 0.75 | NPC1 (0.81) | NPC1ALDH1A1MEN1GAAMAPT | |
| SCHEMBL7929316 | 0.74 | GCK (0.62) | NPC1ALDH1A1KDM4EHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |