Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.55 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | FCER2 | P06734 | 1/20 | 0.33 |
| ▸ | MASP2 | O00187 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | EPOR | P19235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981779 | 0.94 | ADAM17 (0.64) | ADAM17FCER2MMP2MMP3MMP7 | |
| SCHEMBL6939982 | 0.87 | ADAM17 (0.59) | ADAM17GRIK1GRIK2HTR2ACTSC | |
| SCHEMBL6983321 | 0.85 | ADAM17 (0.65) | ADAM17FCER2MMP2MMP3MMP7 | |
| SCHEMBL6945913 | 0.84 | ADAM17 (0.63) | ADAM17GRIK1GRIK2HTR2ACTSC | |
| SCHEMBL6984710 | 0.82 | ADAM17 (0.45) | ADAM17 | |
| Hydrochloric Acid SCHEMBL6982517 | 0.82 | ADAM17 (0.66) | ADAM17FCER2MMP2MMP3MMP7 | |
| SCHEMBL7931029 | 0.82 | ADAM17 (0.57) | ADAM17GRIK1GRIK2HTR2ACTSC | |
| SCHEMBL6986418 | 0.81 | ADAM17 (0.70) | ADAM17FCER2MMP2MMP3MMP7 | |
| SCHEMBL6937771 | 0.81 | ADAM17 (0.69) | ADAM17FCER2MMP2MMP3MMP7 | |
| SCHEMBL6942575 | 0.79 | ADAM17 (0.73) | ADAM17FCER2MMP2MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |