Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 19/20 | 0.62 |
| ▸ | SELE | P16581 | 19/20 | 0.62 |
| ▸ | VCAM1 | P19320 | 7/20 | 0.62 |
| ▸ | CCNC | P24863 | 3/20 | 0.48 |
| ▸ | CDK8 | P49336 | 3/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846856 | 0.91 | ICAM1 (0.66) | ICAM1SELEVCAM1CCNCCDK8 | |
| SCHEMBL7255489 | 0.89 | ICAM1 (0.59) | ICAM1SELEVCAM1CCNCCDK8 | |
| SCHEMBL7053701 | 0.84 | ICAM1 (0.58) | ICAM1SELEVCAM1CCNCCDK8 | |
| SCHEMBL7052567 | 0.84 | CDK8 (0.58) | ICAM1SELEVCAM1CCNCCDK8 | |
| SCHEMBL7797355 | 0.81 | ICAM1 (0.60) | ICAM1SELEVCAM1CCNCCDK8 | |
| SCHEMBL7801846 | 0.81 | CCNC (0.60) | ICAM1SELEVCAM1CCNCCDK8 | |
| SCHEMBL7797361 | 0.79 | ICAM1 (0.55) | ICAM1SELEVCAM1CCNCCDK8 | |
| SCHEMBL7797411 | 0.78 | ICAM1 (0.55) | ICAM1SELEVCAM1CCNCCDK8 | |
| SCHEMBL7797418 | 0.77 | SELE (0.55) | ICAM1SELEVCAM1CCNCCDK8 | |
| SCHEMBL7681347 | 0.77 | ICAM1 (0.55) | ICAM1SELEVCAM1CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232320-B1 | THIENO(2,3-C)PYRIDINE AND 5H-THIENO(2,3-C)PYRAN DERIATIVES | ABBOTT LABORATORIES | 2001-05-15 | — | — | US | disclosed |