SCHEMBL7932024

SCHEMBL7932024

COC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(OC)cc(OC(F)(F)F)n1

nearest known ligand 0.66

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.53
CDK1 P06493 1/20 0.48
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
NPC1 O15118 1/20 0.43
MAPT P10636 2/20 0.42
TP53 P04637 1/20 0.42
GLA P06280 1/20 0.42
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA5A P35218 1/20 0.40
CA9 Q16790 1/20 0.40
PTPN2 P17706 1/20 0.39
PTPN1 P18031 1/20 0.39
PTPN5 P54829 1/20 0.39
SLC40A1 Q9NP59 1/20 0.39
CYP1A2 P05177 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3500652 0.97 GAA (0.48) GAACDK1MEN1KMT2ANPC1
SCHEMBL10645916 0.93 GAA (0.53) GAACDK1MEN1KMT2ANPC1
SCHEMBL1405765 0.92 GAA (0.59) GAACDK1MEN1KMT2ANPC1
SCHEMBL7934034 0.91 GAA (0.47) GAACDK1MEN1KMT2ANPC1
SCHEMBL9740141 0.88 GAA (0.53) GAACDK1MEN1KMT2ANPC1
SCHEMBL9364617 0.87 GAA (0.59) GAACDK1MEN1KMT2ANPC1
SCHEMBL28433647 0.86 GAA (0.45) GAACDK1MEN1KMT2ANPC1
SCHEMBL9467729 0.86 GAA (0.53) GAACDK1MEN1KMT2ANPC1
SCHEMBL10687516 0.85 GAA (0.60) GAACDK1KMT2ANPC1MAPT
SCHEMBL10341393 0.85 GAA (0.52) GAACDK1MEN1KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0446743-B1 Herbicidal sulfonylureas, process for their preparation and intermediates BASF AG (DE) 1995-08-02 EP claimed
US-6235904-B1 VALUABLE INTERMEDIATES FOR ORGANIC SYNTHESES, ESPECIALLY FOR PREPARING CROP PROTECTION AGENTS. BASF AKTIENGESELLSCHAFT (DE) 2001-05-22 US disclosed
US-5283332-A 2-amino(fluoroalkoxy)pyrimidines and the preparation thereof BASF AKTIENGESELLSCHAFT (DE) 1994-02-01 US disclosed
US-5276007-A Herbicidal sulfonylureas BASF AKTIENGESELLSCHAFT (DE) 1994-01-04 US disclosed
US-5237063-A TRIFLUORO- AND CHLORODIFLUOROMETHOXYPYRIMIDINES AND THE PREPARATION THEREOF BASF AKTIENGESELLSCHAFT (DE) 1993-08-17 US disclosed