Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16863658 | 0.80 | AKR1B1 (0.39) | HTR6CYP1A2TSHRAKR1B1MAPT | |
| SCHEMBL6355109 | 0.79 | HTR6 (0.44) | HTR6 | |
| SCHEMBL7624281 | 0.79 | HTR6 (0.47) | HTR6 | |
| SCHEMBL2530115 | 0.78 | AKR1B1 (0.41) | CYP1A2TSHRAKR1B1MAPTPOLB | |
| SCHEMBL7926135 | 0.73 | HTR6 (0.47) | HTR6TSHRMEN1KMT2A | |
| SCHEMBL8096697 | 0.72 | CYP1A2 (0.39) | CYP1A2TSHRMAPTPOLBMEN1 | |
| SCHEMBL6345275 | 0.70 | ACHE (0.35) | HTR6CYP1A2GAAL3MBTL1 | |
| SCHEMBL18435470 | 0.67 | MAPT (0.34) | CYP1A2TSHRAKR1B1MAPTL3MBTL1 | |
| Bicarbonate SCHEMBL29229613 | 0.66 | HTR2A (0.48) | CYP1A2TSHRMAPTPOLBKMT2A | |
| SCHEMBL27461742 | 0.66 | HTR6 (0.48) | HTR6GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300346-B1 | THERAPY OF PRECANCEROUS LESIONS COMPRISING ADMINISTERING INDENYL HYDROXAMIC ACID DERIVATIVE COMPOUND | CELL PATHWAYS, INC. | 2001-10-09 | — | — | US | disclosed |
| US-5929078-A | ANTISEROTONINE AGENT | SYNTHELABO (FR) | 1999-07-27 | — | — | US | disclosed |
| US-5093356-A | Antiallergens, antiasthma, antiinflammatory, cytoprotective | MERCK FROSST CANADA, INC. (CA) | 1992-03-03 | — | — | US | disclosed |