Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 16/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 12/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 12/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.45 |
| ▸ | HRH1 | P35367 | 4/20 | 0.45 |
| ▸ | CCR2 | P41597 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7924086 | 0.81 | ADRA1A (0.55) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7930739 | 0.73 | ADRA1A (0.80) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7930750 | 0.73 | ADRA1A (0.55) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7932828 | 0.70 | ADRA1A (0.57) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7924083 | 0.70 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7934218 | 0.68 | ADRA1A (0.77) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7932384 | 0.68 | ADRA1A (0.77) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7930709 | 0.66 | ADRA1A (0.55) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7930713 | 0.66 | ADRA1A (0.55) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7930756 | 0.66 | ADRA1A (0.50) | ADRA1AADRA1DADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235759-B1 | BENIGN PROSTATIC HYPERPLASIA; HYPOTENSIVE AGENTS | MERCK & CO., INC. | 2001-05-22 | — | — | US | claimed |
| US-6235759-B1 | BENIGN PROSTATIC HYPERPLASIA; HYPOTENSIVE AGENTS | MERCK & CO., INC. | 2001-05-22 | — | — | US | disclosed |