Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12038 | 0.75 | GPR3 (0.33) | — | |
| SCHEMBL3530761 | 0.75 | — | — | |
| SCHEMBL2872387 | 0.75 | TSHR (0.37) | TSHRALDH1A1 | |
| SCHEMBL9588618 | 0.75 | — | — | |
| SCHEMBL29442756 | 0.71 | TSHR (0.58) | TSHRALDH1A1 | |
| SCHEMBL370061 | 0.71 | TSHR (0.58) | TSHRALDH1A1 | |
| SCHEMBL3292005 | 0.67 | — | — | |
| SCHEMBL18329354 | 0.66 | DRD1 (0.36) | — | |
| SCHEMBL15741482 | 0.65 | DRD1 (0.38) | — | |
| SCHEMBL7533426 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723523-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-05-25 | — | — | US | claimed |
| US-20090270378-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | NYCOMED GMBH (DE) | 2009-10-29 | — | — | US | claimed |
| US-20090163538-A1 | Tetrahydropyridothiophenes For Use In The Treatment Of Cancer | PEKARI KLAUS | 2009-06-25 | — | — | US | claimed |
| US-7517986-B2 | Tetrahydropyridothiophenes for use in the treatment of cancer | 4SC AG (DE) | 2009-04-14 | — | — | US | claimed |
| EP-1753512-B1 | TETRAHYDROPYRIDOTHIOPHENES | NYCOMED GMBH (DE) | 2008-07-09 | — | — | EP | claimed |
| EP-1756118-B1 | TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER | NYCOMED GMBH (DE) | 2008-05-28 | — | — | EP | claimed |
| US-20070244112-A1 | Novel tetrahydropyridothiophenes | ALTANA PHARMA AG (DE) | 2007-10-18 | — | — | US | claimed |
| US-20070213360-A1 | Tetrahydropyridothiophenes for Use in the Treatment of Cancer | NYCOMED GMBH (DE) | 2007-09-13 | — | — | US | claimed |
| EP-1756118-A1 | TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER | Altana Pharma AG (DE) | 2007-02-28 | — | — | EP | claimed |
| EP-1753512-A2 | TETRAHYDROPYRIDOTHIOPHENES | Altana Pharma AG (DE) | 2007-02-21 | — | — | EP | claimed |
| EP-1328526-A1 | 3,8-DIAZABICYCLO[3.2.1]OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-07-23 | — | — | EP | claimed |
| WO-2002032902-A1 | 3,8-DIAZABICYCLO[3.2.1]OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-04-25 | — | — | WO | claimed |
| US-5741501-A | Para-hydroxyphenylacetic acid for reducing the repellency of insecticides | BAYER AKTIENGESELLSCHAFT (DE) | 1998-04-21 | — | — | US | claimed |
| EP-0087000-B1 | N-OXALYL DERIVATIVES OF N-METHYL CARBAMATES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PESTICIDES | BAYER AG (DE) | 1985-11-13 | — | — | EP | claimed |
| EP-0129359-A1 | Carbamate insecticides | FBC LIMITED (GB) | 1984-12-27 | — | — | EP | claimed |
| US-4430341-A | INSECTICIDES, MITICIDES | UNION CARBIDE CORPORATION (US) | 1984-02-07 | — | — | US | claimed |
| US-4281011-A | Insecticidal N-methyl-N-(benzene sulfonic acid methylamide-N'-sulfenyl)-carbamic acid oxime esters | BAYER AKTIENGESELLSCHAFT (DE) | 1981-07-28 | — | — | US | claimed |
| US-4272441-A | CARBAMYLATION, PHOSGENE, ALCOHOL, AMINE | FMC CORPORATION (US) | 1981-06-09 | — | — | US | claimed |
| US-4201786-A | INSECTICIDES, MITICIDES | UNION CARBIDE CORPORATION (US) | 1980-05-06 | — | — | US | claimed |
| US-4113876-A | INSECTICIDES, FUNGICIDES, HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270378-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | BAX, BCL2, CCAR2 | TSHR 1110/4885ALDH1A1 686/4885 |
| US-20070244112-A1 | Novel tetrahydropyridothiophenes | BAX, BCL2, BAD | TSHR 1335/4885ALDH1A1 683/4885 |
| US-20090163538-A1 | Tetrahydropyridothiophenes For Use In The Treatment Of Cancer | BCL2, BAX, MCL1 | TSHR 1214/4885ALDH1A1 297/4885 |
| US-20070213360-A1 | Tetrahydropyridothiophenes for Use in the Treatment of Cancer | BCL2, BAX, MCL1 | TSHR 1086/4885ALDH1A1 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.