Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL663962 | 0.98 | ALDH1A1 (0.78) | ALDH1A1CYP3A4TP53TSHRCYP2D6 | |
| Carbamic Acid SCHEMBL28104096 | 0.90 | ALDH1A1 (0.86) | ALDH1A1CYP3A4TP53TSHRCYP2D6 | |
| Carbamic Acid SCHEMBL28652799 | 0.90 | ALDH1A1 (0.86) | ALDH1A1CYP3A4TP53TSHRCYP2D6 | |
| Acetic Acid SCHEMBL866942 | 0.90 | ALDH1A1 (0.93) | ALDH1A1CYP3A4TP53TSHRCYP2D6 | |
| Bicarbonate SCHEMBL5168901 | 0.90 | ALDH1A1 (0.93) | ALDH1A1CYP3A4TP53TSHRCYP2D6 | |
| SCHEMBL5098181 | 0.90 | ALDH1A1 (1.00) | ALDH1A1CYP3A4TP53TSHRCYP2D6 | |
| SCHEMBL5098171 | 0.90 | ALDH1A1 (1.00) | ALDH1A1CYP3A4TP53TSHRCYP2D6 | |
| SCHEMBL2048901 | 0.90 | ALDH1A1 (1.00) | ALDH1A1CYP3A4TP53TSHRCYP2D6 | |
| SCHEMBL15617 | 0.90 | ALDH1A1 (1.00) | ALDH1A1CYP3A4TP53TSHRCYP2D6 | |
| SCHEMBL28847595 | 0.89 | ALDH1A1 (0.83) | ALDH1A1CYP3A4TP53TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115605160-A | Dental prosthesis having structure similar to natural tooth and method for manufacturing the same | 株式会社哈斯（KR） | 2023-01-13 | — | — | CN | claimed |
| EP-3171849-A1 | PROTEIN-REPELLENT DENTAL MATERIALS AND USE THEREOF IN DENTAL APPLICATIONS | The University of Maryland, Baltimore (US) | 2017-05-31 | — | — | EP | claimed |
| WO-2016015005-A1 | PROTEIN-REPELLENT DENTAL MATERIALS AND USE THEREOF IN DENTAL APPLICATIONS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2016-01-28 | — | — | WO | claimed |
| US-4224023-A | Dental restorative kit and method of restoring tooth structure | PENNWALT CORPORATION (US) | 1980-09-23 | — | — | US | claimed |
| CN-113528029-B | Adhesive for preprinting roll paper of corrugated case and preparation method thereof | 马鞍山市康辉纸箱纸品有限公司 | 2023-10-10 | — | — | CN | disclosed |
| CN-113528029-A | Adhesive for preprinted roll paper of corrugated case and preparation method thereof | 马鞍山市康辉纸箱纸品有限公司 | 2021-10-22 | — | — | CN | disclosed |
| CN-104884545-B | Polymer coating composition and coated product | 阿里斯特医疗公司 | 2017-03-22 | — | — | CN | disclosed |
| CN-104884545-A | Polymer coating composition and coated product | ARISTE MEDICAL INC | 2015-09-02 | — | — | CN | disclosed |
| US-6210759-B1 | APPLYING A SINGLE-SOLUTION ADHESIVE RESIN FORMULATION ONTO A PREPARED SURFACE SELECTED FROM THE GROUP CONSISTING OF ENAMEL, DENTIN OR NONPRECIOUS METAL, PHOTOPOLYMERIZING THE ADHESIVE RESIN FORMULATION | AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION | 2001-04-03 | — | — | US | disclosed |
| US-6206959-B1 | BONDING COMPOSITE RESIN TO ENAMEL, DENTIN OR METAL | AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION | 2001-03-27 | — | — | US | disclosed |
| US-6114408-A | COMPRISING NOT MORE THAN TWO POLYMERIZABLE MONOMERS AND A PHOTOINITIATOR, WHEREIN ONE MONOMER IS AN ACIDIC MONOMER FOR PHOTOPOLYMERIZING TO FORM A BINDER | AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION (US) | 2000-09-05 | — | — | US | disclosed |
| US-5362769-A | Light curable; high molecular weight resin, hydrophilic monomer, photoinintiator, reducing agent, leachable fluoride leachable fluoride, acyl peroxide, fillers; wettability, toughness | ORMCO CORPORATION (US) | 1994-11-08 | — | — | US | disclosed |
| WO-1990009230-A1 | COMPOSITE MEMBRANES AND METHOD OF MAKING THE SAME | ISIS INNOVATION LIMITED (GB) | 1990-08-23 | — | — | WO | disclosed |
| US-4224023-A | Dental restorative kit and method of restoring tooth structure | PENNWALT CORPORATION (US) | 1980-09-23 | — | — | US | disclosed |
| US-3997504-A | Composition and method for treating teeth | PLYMALE RICHARD W | 1976-12-14 | — | — | US | disclosed |