Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 14/20 | 0.57 |
| ▸ | LPL | P06858 | 13/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12215766 | 0.88 | LIPG (0.57) | LIPGLPLROCK1EGFRCA1 | |
| SCHEMBL18643675 | 0.87 | ROCK1 (0.56) | LIPGLPLROCK1EGFRCA1 | |
| SCHEMBL28052007 | 0.86 | ROCK1 (0.50) | LIPGLPLROCK1EGFRCA1 | |
| SCHEMBL15100237 | 0.83 | LIPG (0.58) | LIPGLPLROCK1CA1CA2 | |
| SCHEMBL2562597 | 0.83 | ROCK1 (0.52) | LIPGLPLROCK1EGFRCA1 | |
| SCHEMBL31643226 | 0.83 | ROCK1 (0.52) | LIPGLPLROCK1EGFRCA1 | |
| SCHEMBL3321140 | 0.83 | ROCK1 (0.55) | LIPGLPLROCK1EGFRCA1 | |
| SCHEMBL17430653 | 0.83 | ROCK1 (0.52) | LIPGLPLROCK1EGFRCA1 | |
| SCHEMBL27143661 | 0.81 | ROCK1 (0.55) | LIPGLPLROCK1F11HIF1A | |
| SCHEMBL12279506 | 0.81 | LIPG (0.57) | LIPGLPLROCK1EGFRCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616443-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | Exelixis, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012037132-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |