Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.69 |
| ▸ | DRD3 | P35462 | 11/20 | 0.69 |
| ▸ | DRD4 | P21917 | 5/20 | 0.69 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 2/20 | 0.49 |
| ▸ | HTR1B | P28222 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7933887 | 1.00 | DRD2 (0.69) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL8767680 | 0.86 | DRD2 (0.70) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL8767685 | 0.86 | DRD2 (0.70) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL11042664 | 0.85 | DRD2 (0.69) | DRD2DRD3DRD4ADRA1DADRA1A | |
| Bromide SCHEMBL7333392 | 0.85 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL7331896 | 0.85 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL7331890 | 0.85 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| Bromide SCHEMBL7333395 | 0.85 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7424159 | 0.84 | DRD2 (0.71) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL7424155 | 0.84 | DRD2 (0.71) | DRD2DRD3DRD4ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232348-B1 | AGONISTS OF THE DOPAMINERGIC RECEPTORS MORE POTENT THAN DOPAMINE AND OTHER KNOWN COMPOUNDS, DEPRIVED OF INTERACTION WITH OTHER RECEPTORS AND ORALLY BIOAVAILABLE WITH A LONG TERM OF ACTION | ZAMBON GROUP S.P.A. (IT) | 2001-05-15 | — | — | US | disclosed |
| EP-0966423-A1 | HYDROXYMETHYL DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE AS CARDIOVASCULAR AGENT | ZAMBON GROUP S.p.A. (IT) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998038154-A1 | HYDROXYMETHYL DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE AS CARDIOVASCULAR AGENT | ZAMBON GROUP S.P.A. (IT) | 1998-09-03 | — | — | WO | disclosed |