Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | PDE5A | O76074 | 3/20 | 0.57 |
| ▸ | PDE1A | P54750 | 1/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20935220 | 0.84 | PDE5A (0.66) | POLBPDE5APDE1APDE1BPDE1C | |
| SCHEMBL7924468 | 0.81 | POLB (0.58) | POLBPDE5ALMNAMAPK1HDAC1 | |
| SCHEMBL1000799 | 0.80 | PDE5A (0.79) | POLBPDE5APDE1APDE1BPDE1C | |
| SCHEMBL7933437 | 0.78 | POLB (0.50) | POLBPDE5APDE1APDE1BPDE1C | |
| SCHEMBL465934 | 0.78 | SMN1; SMN2 (0.51) | POLBPDE5ALMNAMAPK1GAA | |
| SCHEMBL7933417 | 0.78 | LMNA (0.54) | POLBPDE5APDE1APDE1BPDE1C | |
| SCHEMBL93110 | 0.77 | PDE5A (0.76) | POLBPDE5APDE1APDE1BPDE1C | |
| SCHEMBL20935426 | 0.77 | GAA (0.49) | POLBPDE5APDE1APDE1BPDE1C | |
| SCHEMBL3235298 | 0.76 | HDAC1 (0.54) | PDE5APDE1APDE1BPDE1CLMNA | |
| SCHEMBL3233655 | 0.76 | HDAC1 (0.73) | LMNAMAPK1HDAC1HDAC9HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |