Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19994399 | 0.86 | SMN1; SMN2 (0.65) | POLBSMN1; SMN2MAPK1LMNATSHR | |
| SCHEMBL4099160 | 0.85 | PDE5A (0.58) | POLBSMN1; SMN2MAPK1LMNATSHR | |
| SCHEMBL6824163 | 0.83 | SMN1; SMN2 (0.52) | POLBSMN1; SMN2MAPK1LMNATSHR | |
| SCHEMBL1846537 | 0.81 | CYP1A2 (0.68) | POLBSMN1; SMN2MAPK1LMNATSHR | |
| SCHEMBL6820533 | 0.81 | NPC1 (0.49) | POLBSMN1; SMN2MAPK1LMNATSHR | |
| SCHEMBL7934041 | 0.81 | POLB (0.60) | POLBMAPK1LMNAHDAC1HDAC9 | |
| SCHEMBL7933417 | 0.79 | LMNA (0.54) | POLBMAPK1LMNAHDAC1HDAC9 | |
| SCHEMBL6820510 | 0.78 | NPC1 (0.51) | POLBSMN1; SMN2MAPK1LMNATSHR | |
| SCHEMBL839625 | 0.78 | SMN1; SMN2 (0.63) | POLBSMN1; SMN2MAPK1LMNATSHR | |
| SCHEMBL4097866 | 0.78 | SMN1; SMN2 (0.63) | POLBSMN1; SMN2MAPK1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |