Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 9/20 | 0.50 |
| ▸ | CA1 | P00915 | 8/20 | 0.50 |
| ▸ | CA9 | Q16790 | 5/20 | 0.50 |
| ▸ | CA12 | O43570 | 4/20 | 0.50 |
| ▸ | CA4 | P22748 | 2/20 | 0.49 |
| ▸ | CA7 | P43166 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7929315 | 0.83 | SMN1; SMN2 (0.46) | MEN1KMT2A | |
| SCHEMBL7930891 | 0.83 | POLB (0.50) | MAPTTP53MEN1LMNAKMT2A | |
| SCHEMBL7932092 | 0.81 | KCNQ3 (0.45) | — | |
| SCHEMBL7934021 | 0.78 | NPC1 (0.49) | MAPTALDH1A1 | |
| SCHEMBL7928076 | 0.78 | GCK (0.60) | MAPTALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL7934179 | 0.75 | DYRK3 (0.50) | ALDH1A1KDM4ETP53MEN1KMT2A | |
| SCHEMBL7931544 | 0.71 | CNR2 (0.50) | MAPTALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL14372362 | 0.69 | CA1 (0.77) | CA2CA1CA9CA12CA4 | |
| SCHEMBL14372360 | 0.68 | CA1 (0.63) | CA2CA1CA9CA12MAPT | |
| SCHEMBL7930354 | 0.67 | SMN1; SMN2 (0.47) | MAPTALDH1A1KDM4EMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |