Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.60 |
| ▸ | GRM5 | P41594 | 1/20 | 0.60 |
| ▸ | SCD | O00767 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7929316 | 0.85 | GCK (0.62) | GCKGRM5SCDNPC1RAB9A | |
| SCHEMBL7929315 | 0.82 | SMN1; SMN2 (0.46) | GRM5SMN1; SMN2MEN1KMT2AABL1 | |
| SCHEMBL7934021 | 0.80 | NPC1 (0.49) | GRM5NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7930891 | 0.80 | POLB (0.50) | NPC1RAB9AMAPTMEN1LMNA | |
| SCHEMBL7932092 | 0.78 | KCNQ3 (0.45) | — | |
| SCHEMBL7934176 | 0.78 | CA2 (0.50) | MAPTMEN1LMNAKMT2AKDM4E | |
| SCHEMBL7934179 | 0.74 | DYRK3 (0.50) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL13500910 | 0.69 | CYBB (0.59) | GCKGRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7931544 | 0.69 | CNR2 (0.50) | GRM5NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL30831954 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |