Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 5/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7930891 | 0.85 | POLB (0.50) | BRAF | |
| SCHEMBL7929299 | 0.85 | KCNQ3 (0.43) | KCNQ3KCNQ2KCNE1KCNQ1JAK2 | |
| SCHEMBL7929315 | 0.84 | SMN1; SMN2 (0.46) | JAK2SLC2A1PLAUBRAF | |
| SCHEMBL7934179 | 0.84 | DYRK3 (0.50) | KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL7934176 | 0.81 | CA2 (0.50) | — | |
| SCHEMBL7934021 | 0.79 | NPC1 (0.49) | JAK2MAPK10 | |
| SCHEMBL7928076 | 0.78 | GCK (0.60) | — | |
| SCHEMBL7928993 | 0.76 | RAB9A (0.41) | JAK2KDR | |
| SCHEMBL7932093 | 0.73 | ROCK1 (0.43) | KCNQ3KCNQ2KCNE1KCNQ1JAK2 | |
| SCHEMBL7930350 | 0.70 | POLB (0.51) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |