Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTPRC | P08575 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | LYN | P07948 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6889130 | 0.89 | SYK (0.33) | NPC1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL27495381 | 0.88 | PDCD1 (0.33) | MAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3163965 | 0.87 | PDCD1 (0.35) | MAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29424591 | 0.87 | PDCD1 (0.35) | MAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5709184 | 0.87 | PDCD1 (0.35) | MAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27513156 | 0.86 | HTR2C (0.35) | SLC6A3LCKCSF1RFGFR1PRKACA | |
| Hydrochloric Acid SCHEMBL27513161 | 0.86 | NPC1 (0.35) | NPC1TSHRRAB9ASMN1; SMN2SLC6A3 | |
| Hydrochloric Acid SCHEMBL5617473 | 0.84 | PIK3CD (0.34) | NPC1RAB9ASMN1; SMN2JAK2CYP1A2 | |
| Fluoride Ion SCHEMBL27638234 | 0.84 | PDCD1 (0.35) | MAPK1ALDH1A1 | |
| Iodide SCHEMBL28815111 | 0.84 | PDCD1 (0.35) | MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010014718-A1 | RESIN COMPOSITIONS AND USE OF THE SAME | MITSUI CHEMICALS, INC. (JP) | 2001-08-16 | — | — | US | disclosed |
| EP-0801047-B1 | NORBORNENE COMPOUNDS HAVING CHAIN POLYENE GROUPS AND UNSATURATED ETHYLENIC COPOLYMER PRODUCED WITH THE USE OF THE SAME | MITSUI CHEMICALS INC (JP) | 2000-04-05 | — | — | EP | disclosed |
| CN-1217685-A | VULCANIZED MOLDING HAVING SURFACE DECORATIVE LAYER, PAINTED THERMOPLASTIC RESIN COMPOSITION AND PAINTED ELASTOMER COMPOSITION | MITSUI CHEMICALS INC (JP) | 1999-05-26 | — | — | CN | disclosed |
| CN-1216053-A | SHRINKABLE FILM MADE FROM OLEFINE COPOLYMER | MITSUI CHEMICALS INC (JP) | 1999-05-05 | — | — | CN | disclosed |
| CN-1216055-A | RUBBER COMPOSITIONS FOR TIRES | MITSUI CHEMICALS INC (JP) | 1999-05-05 | — | — | CN | disclosed |