Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7934283 | 0.89 | MAOA (0.32) | NPC1ALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL27495381 | 0.89 | PDCD1 (0.33) | EDNRBEDNRAALDH1A1 | |
| Hydrochloric Acid SCHEMBL29424591 | 0.89 | PDCD1 (0.35) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3163965 | 0.89 | PDCD1 (0.35) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5709184 | 0.89 | PDCD1 (0.35) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27513161 | 0.88 | NPC1 (0.35) | EDNRBEDNRANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL27513156 | 0.88 | HTR2C (0.35) | — | |
| Hydrochloric Acid SCHEMBL5617473 | 0.86 | PIK3CD (0.34) | NPC1ALDH1A1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL28878594 | 0.86 | BRD4 (0.32) | — | |
| Iodide SCHEMBL28815111 | 0.85 | PDCD1 (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101124252-B | Metallocene catalysts, their synthesis and use in olefin polymerization | NOVOLEN TECH HOLDINGS CV | 2011-10-05 | — | — | CN | claimed |
| CN-1946748-B | Metallocene ligands, metallocene compounds and metallocene catalysts, their synthesis and their use for the polymerization of olefins | NOVOLEN TECH HOLDINGS CV | 2011-04-06 | — | — | CN | claimed |
| CN-101124252-A | Metallocene catalysts, their synthesis and use in olefin polymerization | NOVOLEN TECH HOLDINGS CV (NL) | 2008-02-13 | — | — | CN | claimed |
| CN-1946748-A | Metallocene ligands, metallocene compounds and metallocene catalysts, their synthesis and their use for the polymerization of olefins | NOVOLEN TECH HOLDINGS CV (NL) | 2007-04-11 | — | — | CN | claimed |
| CN-103012623-B | Metalloscene catalyst, its synthesis and purposes in olefin polymerization | NOVOLEN TECH HOLDINGS CV (DE) | 2015-09-16 | — | — | CN | disclosed |
| CN-103012623-A | Metallocene catalysts, their synthesis and their use for the polymerization of olefins | NOVOLEN TECH HOLDINGS CV | 2013-04-03 | — | — | CN | disclosed |
| CN-101384624-B | Catalyst composition for olefin polymerization | NOVOLEN TECH HOLDINGS CV | 2012-07-04 | — | — | CN | disclosed |
| CN-101124252-B | Metallocene catalysts, their synthesis and use in olefin polymerization | NOVOLEN TECH HOLDINGS CV | 2011-10-05 | — | — | CN | disclosed |
| CN-1946748-B | Metallocene ligands, metallocene compounds and metallocene catalysts, their synthesis and their use for the polymerization of olefins | NOVOLEN TECH HOLDINGS CV | 2011-04-06 | — | — | CN | disclosed |
| CN-101511879-A | Preparation of polymerization catalyst activators utilizing indole-modified silica supports | EXXONMOBIL CHEM PATENTS INC (US) | 2009-08-19 | — | — | CN | disclosed |
| CN-101384624-A | Catalyst composition for olefin polymerization | NOVOLEN TECH HOLDINGS CV (NL) | 2009-03-11 | — | — | CN | disclosed |
| CN-101124252-A | Metallocene catalysts, their synthesis and use in olefin polymerization | NOVOLEN TECH HOLDINGS CV (NL) | 2008-02-13 | — | — | CN | disclosed |
| WO-2001062832-A1 | PROCESS FOR THE PREPARATION OF ADDITIVE COATED MOLDING POWDER | BOREALIS TECHNOLOGY OY (FI) | 2001-08-30 | — | — | WO | disclosed |
| US-20010014718-A1 | RESIN COMPOSITIONS AND USE OF THE SAME | MITSUI CHEMICALS, INC. (JP) | 2001-08-16 | — | — | US | disclosed |
| EP-1123319-A2 | SUPPORTED POLYMERIZATION CATALYSTS | Borealis Technology (FI) | 2001-08-16 | — | — | EP | disclosed |
| CN-1281871-A | Flexible resin composition and its use | MITSUI CHEMICALS INC (JP) | 2001-01-31 | — | — | CN | disclosed |
| WO-2000022011-A2 | SUPPORTED POLYMERIZATION CATALYSTS | BOREALIS TECHNOLOGY OY (FI) | 2000-04-20 | — | — | WO | disclosed |
| CN-1217685-A | VULCANIZED MOLDING HAVING SURFACE DECORATIVE LAYER, PAINTED THERMOPLASTIC RESIN COMPOSITION AND PAINTED ELASTOMER COMPOSITION | MITSUI CHEMICALS INC (JP) | 1999-05-26 | — | — | CN | disclosed |
| CN-1216053-A | SHRINKABLE FILM MADE FROM OLEFINE COPOLYMER | MITSUI CHEMICALS INC (JP) | 1999-05-05 | — | — | CN | disclosed |
| CN-1216055-A | RUBBER COMPOSITIONS FOR TIRES | MITSUI CHEMICALS INC (JP) | 1999-05-05 | — | — | CN | disclosed |