Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 11/20 | 0.61 |
| ▸ | DPP7 | Q9UHL4 | 10/20 | 0.61 |
| ▸ | PREP | P48147 | 4/20 | 0.61 |
| ▸ | FAP | Q12884 | 7/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 5/20 | 0.48 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 6/20 | 0.44 |
| ▸ | REN | P00797 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PEPD | P12955 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19165611 | 1.00 | DPP4 (0.61) | DPP4DPP7PREPFAPDPP8 | |
| SCHEMBL23794392 | 0.89 | DPP4 (0.60) | DPP4DPP7PREPFAPDPP8 | |
| SCHEMBL10056862 | 0.89 | DPP4 (0.60) | DPP4DPP7PREPFAPDPP8 | |
| SCHEMBL14865113 | 0.89 | DPP4 (0.60) | DPP4DPP7PREPFAPDPP8 | |
| SCHEMBL8892746 | 0.87 | DPP4 (0.61) | DPP4DPP7PREPFAPDPP8 | |
| SCHEMBL22542490 | 0.87 | DPP4 (0.61) | DPP4DPP7PREPFAPACE | |
| SCHEMBL8892750 | 0.87 | DPP4 (0.61) | DPP4DPP7PREPFAPDPP8 | |
| SCHEMBL24419900 | 0.87 | DPP4 (0.61) | DPP4DPP7PREPFAPACE | |
| SCHEMBL19167069 | 0.87 | DPP4 (0.61) | DPP4DPP7PREPFAPDPP8 | |
| SCHEMBL12285674 | 0.85 | DPP4 (0.58) | DPP4DPP7PREPFAPDPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9802946-B2 | NMDA receptor modulators and uses thereof | NORTHWESTERN UNIVERSITY (US) | 2017-10-31 | — | — | US | disclosed |
| US-9593145-B2 | Secondary structure stabilized NMDA receptor modulators and uses thereof | NORTHWESTERN UNIVERSITY (US) | 2017-03-14 | — | — | US | disclosed |
| US-9512133-B2 | NMDA receptor modulators and uses thereof | NORTHWESTERN UNIVERSITY (US) | 2016-12-06 | — | — | US | disclosed |
| US-20160115197-A1 | SECONDARY STRUCTURE STABILIZED NMDA RECEPTOR MODULATORS AND USES THEREOF | INNOVIVA TRC HOLDINGS LLC | 2016-04-28 | — | — | US | disclosed |
| US-20150336969-A1 | NMDA Receptor Modulators and Uses Thereof | NAUREX, INC. | 2015-11-26 | — | — | US | disclosed |
| US-9101612-B2 | Secondary structure stabilized NMDA receptor modulators and uses thereof | NORTHWESTERN UNIVERSITY (US) | 2015-08-11 | — | — | US | disclosed |
| US-20150105364-A1 | NMDA Receptor Modulators and Uses Thereof | NORTHWESTERN UNIVERSITY (US) | 2015-04-16 | — | — | US | disclosed |
| WO-2011100585-A1 | SECONDARY STRUCTURE STABILIZED NMDA RECEPTOR MODULATORS AND USES THEREOF | MOSKAL JOSEPH (US) | 2011-08-18 | — | — | WO | disclosed |
| WO-2010033757-A1 | NMDA RECEPTOR MODULATORS AND USES THEREOF | NAUREX, INC. (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336969-A1 | NMDA Receptor Modulators and Uses Thereof | GRIN1, GRIN2A, GRIN3A | DPP4 1413/4885DPP7 1615/4885PREP 3459/4885 |
| US-20150105364-A1 | NMDA Receptor Modulators and Uses Thereof | GRIN1, GRIN2A, GRIN3A | DPP4 1413/4885DPP7 1615/4885PREP 3459/4885 |
| US-20160115197-A1 | SECONDARY STRUCTURE STABILIZED NMDA RECEPTOR MODULATORS AND USES THEREOF | GRIN2A, GRIN1, GRIN3A | DPP4 2491/4885DPP7 2430/4885PREP 3855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.