Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7926943 | 0.89 | RAB9A (0.32) | TP53NPC1RAB9ASMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL7932997 | 0.84 | CYP3A4 (0.32) | — | |
| Hydrochloric Acid SCHEMBL7938774 | 0.78 | TP53 (0.33) | TP53NPC1RAB9ASMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL7938847 | 0.74 | NISCH (0.33) | — | |
| Hydrochloric Acid SCHEMBL7926698 | 0.73 | TP53 (0.32) | TP53NPC1RAB9ASMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL7933256 | 0.72 | PTPN1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL7926715 | 0.66 | NISCH (0.33) | — | |
| Hydrochloric Acid SCHEMBL7933168 | 0.66 | TP53 (0.32) | TP53 | |
| Hydrochloric Acid SCHEMBL7938776 | 0.66 | TP53 (0.34) | TP53NPC1RAB9ASMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL7938755 | 0.62 | NISCH (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |