Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.70 |
| ▸ | LMNA | P02545 | 7/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | LIPE | Q05469 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11360493 | 0.89 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNARAB9AHTTHPGD | |
| SCHEMBL6503509 | 0.88 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNARAB9AHTTHPGD | |
| SCHEMBL14649861 | 0.86 | SMN1; SMN2 (0.70) | SMN1; SMN2LMNARAB9AHTTHPGD | |
| SCHEMBL9198717 | 0.86 | SMN1; SMN2 (0.70) | SMN1; SMN2LMNARAB9AHTTHPGD | |
| SCHEMBL7943182 | 0.86 | SMN1; SMN2 (0.73) | SMN1; SMN2LMNARAB9AHTTHPGD | |
| SCHEMBL11459158 | 0.84 | SMN1; SMN2 (0.66) | SMN1; SMN2LMNARAB9AHTTHPGD | |
| SCHEMBL17051146 | 0.84 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNARAB9AHTTHPGD | |
| SCHEMBL9790809 | 0.83 | LMNA (0.67) | SMN1; SMN2LMNARAB9AHTTHPGD | |
| SCHEMBL11196331 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNARAB9AHTTHPGD | |
| SCHEMBL12585076 | 0.82 | LMNA (0.64) | SMN1; SMN2LMNARAB9AHTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |