Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.58 |
| ▸ | HTR2C | P28335 | 8/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27740032 | 0.82 | NFE2L2 (0.47) | HTR2AHTR2CHTR2BGRM5FEN1 | |
| SCHEMBL776706 | 0.82 | HTR6 (0.57) | HTR2AHTR2CHTR2BKCNH2HSD11B1 | |
| SCHEMBL775608 | 0.82 | HTR2C (0.59) | HTR2AHTR2CHTR2BKCNH2FEN1 | |
| SCHEMBL777135 | 0.80 | HTR6 (0.61) | HTR2AHTR2CHTR2BKCNH2KAT6A | |
| SCHEMBL1988091 | 0.80 | AKR1B1 (0.48) | HTR2AHTR2CHTR2BGRM5FEN1 | |
| SCHEMBL16494923 | 0.80 | NFE2L2 (0.47) | HTR2AHTR2CHTR2BGRM5KCNH2 | |
| SCHEMBL2474755 | 0.79 | HTR2A (0.59) | HTR2AHTR2CHTR2BKCNH2HSD11B1 | |
| SCHEMBL29046704 | 0.78 | KAT6A (0.48) | HTR2AHTR2CHTR2BFEN1KAT6A | |
| SCHEMBL250919 | 0.77 | AKR1B1 (0.53) | HTR2AHTR2CHTR2BKAT6ANFE2L2 | |
| SCHEMBL30333632 | 0.77 | AKR1B1 (0.53) | HTR2AHTR2CHTR2BKAT6ANFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242654-B1 | REACTING A PHENOLATE COMPOUND WITH AN ORGANIC FLUORINATING AGENT TO PREPARE A FLUORINE SUBSTITUTED AROMATIC COMPOUND | MITSUI CHEMICALS, INC. (JP) | 2001-06-05 | — | — | US | disclosed |
| EP-1013629-A1 | Preparation process of fluorine subsituted aromatic compound | Mitsui Chemicals, Inc. (JP) | 2000-06-28 | — | — | EP | disclosed |