Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2525982 | 0.90 | PDCD1 (0.34) | ADRA2AADRA2BADRA2CCHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL29564499 | 0.90 | PDCD1 (0.34) | ADRA2AADRA2BADRA2CCHRNB2CHRNA4 | |
| Fluoride Ion SCHEMBL7636064 | 0.87 | PDCD1 (0.34) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL6553574 | 0.86 | PDCD1 (0.32) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL21980378 | 0.84 | PDCD1 (0.33) | — | |
| Hydrochloric Acid SCHEMBL8633266 | 0.84 | PDCD1 (0.30) | — | |
| Hydrochloric Acid SCHEMBL7933266 | 0.84 | MAPT (0.34) | — | |
| Hydrochloric Acid SCHEMBL7933229 | 0.82 | ADRA2A (0.33) | ADRA2AADRA2BADRA2CCHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL8628885 | 0.81 | TNF (0.35) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL8633278 | 0.81 | CA12 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |