Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CD44 | P16070 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163816 | 0.82 | CYP3A4 (0.59) | TSHRCYP3A4PIK3CAALDH1A1CD44 | |
| SCHEMBL8173503 | 0.82 | CYP3A4 (0.59) | TSHRCYP3A4PIK3CAALDH1A1CD44 | |
| SCHEMBL29871801 | 0.82 | CYP3A4 (0.59) | TSHRCYP3A4PIK3CAALDH1A1CD44 | |
| SCHEMBL168119 | 0.79 | CYP3A4 (0.43) | TSHRCYP3A4PIK3CAALDH1A1CA2 | |
| SCHEMBL27390124 | 0.78 | CYP3A4 (0.54) | TSHRCYP3A4PIK3CAALDH1A1CD44 | |
| SCHEMBL330603 | 0.76 | TSHR (0.56) | TSHRCYP3A4PIK3CAALDH1A1CD44 | |
| SCHEMBL2975923 | 0.75 | CYP3A4 (0.50) | TSHRCYP3A4PIK3CAALDH1A1CD44 | |
| Benzene SCHEMBL28248705 | 0.74 | TSHR (0.54) | TSHRCYP3A4PIK3CAALDH1A1CD44 | |
| SCHEMBL5535338 | 0.74 | SMN1; SMN2 (0.49) | TSHRCYP3A4PIK3CAALDH1A1CD44 | |
| SCHEMBL30289 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598179-B1 | CALCIUM PARTICLE-EMBEDDED, SNAP-TO-DOUGH, HIGH-VISCOSITY BONE CEMENT | WARSAW ORTHOPEDIC INC (US) | 2016-05-11 | — | — | EP | claimed |
| CN-108770341-B | Bone void filler with calcium coating | 华沙整形外科股份有限公司 | 2021-05-25 | — | — | CN | disclosed |
| EP-0676212-B1 | Method for forming bone cement to an implant | BRISTOL MYERS SQUIBB CO (US) | 2001-10-17 | — | — | EP | disclosed |
| US-5538514-A | Method for forming bone cement to an implant | ZIMMER, INC. (US) | 1996-07-23 | — | — | US | disclosed |
| EP-0676212-A1 | Method for forming bone cement to an implant | Bristol-Myers Squibb Company (US) | 1995-10-11 | — | — | EP | disclosed |
| US-4791150-A | Composition for use in making bone cement | BONAR COLE POLYMERS LIMITED (GB) | 1988-12-13 | — | — | US | disclosed |
| EP-0218471-A1 | Bone cement | BONAR COLE POLYMERS LIMITED (GB) | 1987-04-15 | — | — | EP | disclosed |